鑫郭
在太平洋自从: 2003
鑫郭, PhD earned his bachelor of science in medicinal chemistry from Fudan University in Shanghai, China in 1993 and his master of science in medicinal chemistry from Duquesne University School of 药店 in Pittsburgh, 1995年在宾夕法尼亚州. He earned his doctor of philosophy in pharmaceutical chemistry from University of California, 2001年的旧金山. Dr. Guo has been a part of the Pacific family since 2003.
As a Pacific faculty member, Dr. Guo loves the opportunity to give energizing lectures on medications and to mentor pre-pharmacy students. He also enjoys being involved in the Beta Omega chapter of the Rho Chi Honor Society because of the youthful exuberance and team spirit of the students. His goals are to inspire students, advance science in drug delivery and help Pacific excel in the field of pharmaceutics and medicinal chemistry.
Dr. Guo is a member of the American Association of Pharmaceutical Scientists and has served as Chair for the organization's Bay Area Discussion Group. In addition, he is a member of the American Chemical Society.
He enjoys singing, traveling and playing chess. He is a member of his church choir and is a small group leader.
1993年，复旦大学理学学士
杜肯大学硕士，1995年
PhD, University of California, San Francisco, 2001
PostDoc, Buck Institute of Age 研究 and University of California, San Francisco, 2001-2003
教学理念
“To inspire the students to learn actively and to think deeply.”
课程
PHRM136 — Pharmacology and Medicinal Chem II
PRAC149 — Peer Tutoring and Mentoring
PHRM 191 -独立研究
PCSP213 — Biotransformation of Pharmaceutical Agents
PCSP 229 — Advances in Drug Delivery Systems
PCSP 297/397 — 研究生 研究
PCSP 299/399 — Thesis/Dissertation
研究总结
“My re搜索 group is interested in developing smart, nanometer sized formulations that carry medicines to their target sites in the body to enhance their therapeutic activity and safety. Our current projects include the design of liposomes with a pH-sensitive conformational switch for triggered release of anticancer drugs in solid tumors, and liposome-coated phosphate nanoparticles for the delivery of proteins into the cytosol. 我们使用各种物理设备, chemical and biological approaches to design and characterize such novel drug formulations.”
研究兴趣
- Novel pH-sensitive liposomes for the delivery of small-molecule drugs, proteins and nucleic acids
- Anticancer drugs and their liposomal formulations for drug targeting
- Design, preparation and characterization of pH-sensitive cationic lipids for gene delivery
- Liposome formulation of anticancer peptides and proteins
- Liver-targeting lipidic particles based on recombinant high density lipoprotein
- Protein-folding studies using chemical crosslinking coupled with mass spectrometry
学术活动
Ruiqi Huang ’20, Vijay Gyanani ’13, PhD, Shen Zhao ’18, PhD, Yifan Lu ’19, PhD and 鑫郭, PhD, professor of pharmaceutics and medicinal chemistry, published “Imidazole-Based pH-Sensitive Convertible Liposomes for Anticancer Drug Delivery” in Pharmaceuticals 2022, March 3, 2022.
鑫郭, $3,200 正规博彩十大网站 Scholarly Artistic Activity Grant “Nanometer Assemblies of Drug Molecules versus Micrometer Clusters of Cancer Cells: Putting Scientific Innovations to Clinical Challenges.”
Yingbu Huang, Yifan Lu, Mallika Vadlamudi, Shen Zhao, Melanie Felmlee, Roshanak Rahimian, 鑫郭 "Intrapulmonary inoculation of multicellular spheroids to construct an orthotopic lung cancer xenograft model that mimics four clinical stages of non-small cell lung cancer" J Pharmacol Toxicol Methods. 2020年6月
Yunzhou Fang, Mallika Vadlamudi, Yingbo Huang, 鑫郭 “Lipid-Coated, pH-Sensitive Magnesium Phosphate Particles for Intracellular Protein Delivery” Pharmaceutical 研究, 2019年6月.
刘,X.; 郑,Y.; Samoshina N.M.; Franz, A.H.; 郭,X.; Samoshin, V.V. Fliposomes: pH-triggered conformational flip of new trans-2-aminocyclohexanol-based amphiphiles causes instant cargo release in liposomes. J脂质体. 2012年7月9日. [印前Epub]
陈,H.; Zhang, H.; Thor, D.; Rahimian, R.; 郭,X. Novel pH-sensitive cationic lipids with linear ortho ester linkers for gene delivery. Eur 医学化学 2012, 52:159-72.
郑,Y.; 刘,X.; Samoshina N. M.; Chertkovc, V.A.; Franza, A. H.; 郭,X.; Samoshin, V.V. Fliposomes: pH-controlled release from liposomes containing new trans-2-morpholinocyclohexanol-based amphiphiles that perform a conformational flip and trigger an instant cargo release upon acidification. Nat产品通讯. 2011. 6, 1-3.
Samoshina N.M.; 刘,X.; Brazdova, B.; Franz, A. H.; Samoshin, V.V.; 鑫郭, X. Fliposomes: pH-Sensitive liposomes containing a trans-2-morpholinocyclohexanol-based lipid that performs a conformational flip and triggers an instant cargo release in acidic medium. Pharmaceutics 2011, 3(3), 379-405.
Brazdova, B; Zhang, N; Samoshin V. V.; 郭,X. trans-2-Aminocyclohexanol as a pH-sensitive conformational switch in lipid amphiphiles. 化学通讯. 2008. DOI: 10.1039/B807704E.
陈,H.; Zhang, H.; McCallum, C.M.; Szoka, F. C.; 郭,X. Unsaturated cationic ortho esters for endosome permeation in gene delivery. 医学化学. 2007, 50, 4269-78.
